Methyl isobutyryl acetate CAS 42558-54-3 for Atorvastatin Intermediate M4

Methyl isobutyryl acetate CAS 42558-54-3 for Atorvastatin Intermediate M4
Methyl isobutyryl acetate CAS 42558-54-3 for Atorvastatin Intermediate M4
MOQ
1T
CAS
42558-54-3
Molecular formula
C7H12O3
Package
Iron drum or plastic lined drum
Content
98%
Specification
25㎏,50㎏,200㎏
Storage
Sealed and protected from light
Methyl isobutyryl acetate (CAS 42558-54-3) plays a crucial role as an intermediate compound in the synthesis of pharmaceuticals, notably in the production of Atorvastatin, a widely prescribed medication for lowering cholesterol levels in the bloodstream.

Methyl isobutyryl acetate (CAS 42558-54-3) plays a crucial role as an intermediate compound in the synthesis of pharmaceuticals, notably in the production of Atorvastatin, a widely prescribed medication for lowering cholesterol levels in the bloodstream. This article delves into the significance of methyl isobutyryl acetate as an essential component in the synthesis of Atorvastatin Intermediate M4.

Alias: Methyl Isobutyryl Acetate; 2-Methylpropionyl methyl acetate; Isobutylacetic Acid methyl ester;

Isobutyrylacetic Acid Methyl Ester;ISO-butyryl Methyl Acetate; MIBA; M1

Methyl-isobutyryl-acetate.webp

Synthesis of Atorvastatin Intermediate M4

 Atorvastatin, a statin drug used to prevent cardiovascular diseases, is synthesized through several chemical reactions involving various intermediates. Among these, Atorvastatin Intermediate M4 holds particular importance. Methyl isobutyryl acetate, with its CAS number 42558-54-3, acts as a vital precursor in the synthesis pathway leading to Intermediate M4.

Role of Methyl Isobutyryl Acetate

Methyl isobutyryl acetate serves as a key building block in the synthesis of Atorvastatin Intermediate M4. Its unique chemical properties and reactivity allow it to undergo controlled reactions with other compounds, leading to the formation of the desired intermediate. This intermediate is subsequently transformed into Atorvastatin through additional chemical steps.

Chemical Properties and Reactivity

Methyl isobutyryl acetate is a colorless liquid with a characteristic fruity odor. Its chemical structure consists of an acetate group (-COOCH3) attached to an isobutyryl group (-CH(CH3)2). This compound exhibits moderate reactivity, making it suitable for use in organic synthesis processes. The acetate group serves as a leaving group in various reactions, facilitating the formation of new bonds with other molecules.

Synthesis Pathway

The synthesis of Atorvastatin Intermediate M4 involving methyl isobutyryl acetate typically follows a multi-step pathway. In one common approach, methyl isobutyryl acetate undergoes hydrolysis to yield isobutyric acid and methanol. Isobutyric acid then reacts with an appropriate amine compound to form the corresponding amide derivative. Subsequent chemical transformations lead to the formation of Atorvastatin Intermediate M4.

Purity and Quality Control

The purity of methyl isobutyryl acetate is of utmost importance in pharmaceutical synthesis. Impurities in the intermediate can adversely affect the quality and efficacy of the final product. Therefore, rigorous quality control measures, including analytical techniques such as gas chromatography and spectroscopy, are employed to ensure the purity and consistency of the compound.

Methyl isobutyryl acetate, with its CAS number 42558-54-3, serves as a critical intermediate in the synthesis of Atorvastatin Intermediate M4. Its unique chemical properties and reactivity make it an indispensable component in the production of Atorvastatin, a widely used medication for managing cholesterol levels and preventing cardiovascular diseases. Through meticulous synthesis pathways and quality control measures, methyl isobutyryl acetate contributes to the pharmaceutical industry's efforts in providing safe and effective treatments for various health conditions.

FAQ

1. What is Methyl Isobutyryl Acetate (CAS 42558-54-3)?
Methyl isobutyryl acetate is a chemical compound commonly used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals. With CAS number 42558-54-3, it is a colorless liquid with a fruity odor.

2. What is the role of Methyl Isobutyryl Acetate in Atorvastatin synthesis?
Methyl isobutyryl acetate plays a crucial role as an intermediate compound in the synthesis of Atorvastatin, a medication used to lower cholesterol levels. Specifically, it serves as a precursor in the synthesis pathway leading to Atorvastatin Intermediate M4.

3. How does Methyl Isobutyryl Acetate contribute to the synthesis of Atorvastatin Intermediate M4?
Methyl isobutyryl acetate undergoes controlled chemical reactions with other compounds in the synthesis pathway to form Atorvastatin Intermediate M4. Its unique chemical properties and reactivity enable the formation of the desired intermediate, which is subsequently transformed into Atorvastatin.

4. What are the chemical properties of Methyl Isobutyryl Acetate?
Methyl isobutyryl acetate is a colorless liquid with a characteristic fruity odor. Its chemical structure consists of an acetate group (-COOCH3) attached to an isobutyryl group (-CH(CH3)2). It exhibits moderate reactivity, making it suitable for use in organic synthesis processes.

5. How is the purity of Methyl Isobutyryl Acetate ensured in pharmaceutical synthesis?
The purity of Methyl Isobutyryl Acetate is crucial in pharmaceutical synthesis to ensure the quality and efficacy of the final product. Rigorous quality control measures, including analytical techniques such as gas chromatography and spectroscopy, are employed to monitor and maintain its purity.

6. What is the synthesis pathway involving Methyl Isobutyryl Acetate in Atorvastatin production?
The synthesis pathway typically involves the hydrolysis of Methyl Isobutyryl Acetate to yield isobutyric acid and methanol. Isobutyric acid then reacts with an appropriate amine compound to form the corresponding amide derivative, leading to the formation of Atorvastatin Intermediate M4.

7. Why is Methyl Isobutyryl Acetate important in the pharmaceutical industry?
Methyl isobutyryl acetate is important in the pharmaceutical industry due to its role as an intermediate in the synthesis of various medications, including Atorvastatin. Its controlled reactivity and versatility make it a valuable component in organic synthesis processes.

8. Are there any safety considerations associated with Methyl Isobutyryl Acetate?
As with handling any chemical compound, proper safety precautions should be followed when working with Methyl Isobutyryl Acetate. This includes wearing appropriate personal protective equipment, working in a well-ventilated area, and following established protocols for storage and handling.

9. Where can Methyl Isobutyryl Acetate be sourced for industrial purposes?
Methyl Isobutyryl Acetate can typically be sourced from chemical suppliers specializing in fine chemicals and intermediates for pharmaceutical synthesis. It is important to ensure that the supplier adheres to strict quality control standards to guarantee the purity and consistency of the product.

10. How does the use of Methyl Isobutyryl Acetate contribute to the production of high-quality pharmaceuticals like Atorvastatin?
The use of Methyl Isobutyryl Acetate as an intermediate in Atorvastatin synthesis allows for the production of high-quality pharmaceuticals with consistent efficacy and safety profiles. Its controlled reactivity and purity ensure the integrity of the synthesis process, ultimately contributing to the development of effective medications for managing cholesterol levels and preventing cardiovascular diseases.


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Name: Robert J        time:2024-03-05 15:24:44
We need 3 tons of methyl isobutyrylacetate; methyl isobutyrylacetate; methyl 2-methylpropionylacetate.

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